I have done it using javascript. But i have to do it on server side.
function Validate()
{
var x = ctl00_txtMobileno.value;
if (x.charAt(0)=="0" || x.length !=10 || isNaN(x)||x.indexOf(" ")!=-1)
{
alert("Enter correct 10 digit mobile number. It should not start with Zero !!");
ctl00_txtMobileno.focus();
return false;
}
}