Add the run-without-debugging icon to the toolbar. Your problem is you forget the hotkey, and click the icon. So remove the other icon, or move them both around, like this:
The bigger your application grows, I find, the slower the debugger startup gets. I run without debugging about 99% of the time now, because the startup time of my app goes from 2 seconds, to 2 minutes, because it uses a lot of runtime packages, and every BPL load in the debugger comes at a huge hit to my productivity. So long, slow painful experience has re-educated me to ask myself "Do I really need to debug?". If I don't, I click the nice green icon (in XE) that replaces the exclamation mark icon in older versions. (A smart UI improvement I think.). In previous delphi versions, the green play button meant "run with debugging".