我已经看到了Harsh Gupta 的票“无法加载文件或程序集 'Magick.NET-x86.DLL' 或其依赖项之一”，我遇到了同样的问题，但没有这些解决方案适合我。
我有一个包含 ImageMagick 的 Web 应用程序，它新安装在新的 Windows Server 2012 实例上（我们正在从 Windows Server 2008 R2 实例迁移到该实例）。该应用程序在 Server 2008 和本地运行正常，但在 Server 2012 上运行不正常。
我在将 Magick.Net 从 6.8.7.502 升级到 7.0.7.300 后重建了项目，希望7.0.6 中引入的自述文件中提到的 .Net Standard / .Net Core 支持能够解决我的问题，但是徒劳无功。在此之前，我还安装了 VC++ 2012 和 2015，正如 Harsh Gupta在他们接受的答案中提到的那样。
尽管如此，我仍然收到“HTTP 错误 500.0 - 内部服务器错误”页面，告诉我：
模块： AspNetInitializationExceptionModule
通知： BeginRequest
处理程序： ExtensionlessUrlHandler-Integrated-4.0
错误代码： 0x00000000
请求的 URL： [已编辑]
物理路径： [已编辑，但正确]
登录方法：尚未确定
登录用户：尚未确定
事件日志显示来自 ASP.NET 4.0.30319.0 的警告事件，事件 ID 为 1310 和以下堆栈跟踪：
Event code: 3008
Event message: A configuration error has occurred.
Event time: 9/20/2017 6:20:40 PM
Event time (UTC): 9/20/2017 6:20:40 PM
Event ID: 4775ecdb4601401ca30aa057f77ae78a
Event sequence: 1
Event occurrence: 1
Event detail code: 0
Application information:
Application domain: [redacted]
Trust level: Full
Application Virtual Path: /
Application Path: [redacted]
Machine name: [redacted]
Process information:
Process ID: 5096
Process name: w3wp.exe
Account name: IIS APPPOOL\[redacted]
Exception information:
Exception type: ConfigurationErrorsException
Exception message: Could not load file or assembly 'Magick.NET-x86.DLL' or one of its dependencies. The specified module could not be found.
at System.Web.Configuration.CompilationSection.LoadAssemblyHelper(String assemblyName, Boolean starDirective)
at System.Web.Configuration.CompilationSection.LoadAllAssembliesFromAppDomainBinDirectory()
at System.Web.Configuration.CompilationSection.LoadAssembly(AssemblyInfo ai)
at System.Web.Compilation.BuildManager.GetReferencedAssemblies(CompilationSection compConfig)
at System.Web.Compilation.BuildManager.GetPreStartInitMethodsFromReferencedAssemblies()
at System.Web.Compilation.BuildManager.CallPreStartInitMethods(String preStartInitListPath, Boolean& isRefAssemblyLoaded)
at System.Web.Compilation.BuildManager.ExecutePreAppStart()
at System.Web.Hosting.HostingEnvironment.Initialize(ApplicationManager appManager, IApplicationHost appHost, IConfigMapPathFactory configMapPathFactory, HostingEnvironmentParameters hostingParameters, PolicyLevel policyLevel, Exception appDomainCreationException)
Could not load file or assembly 'Magick.NET-x86.DLL' or one of its dependencies. The specified module could not be found.
at System.Reflection.RuntimeAssembly._nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks)
at System.Reflection.RuntimeAssembly.nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks)
at System.Reflection.RuntimeAssembly.InternalLoadAssemblyName(AssemblyName assemblyRef, Evidence assemblySecurity, RuntimeAssembly reqAssembly, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks)
at System.Reflection.RuntimeAssembly.InternalLoad(String assemblyString, Evidence assemblySecurity, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean forIntrospection)
at System.Reflection.RuntimeAssembly.InternalLoad(String assemblyString, Evidence assemblySecurity, StackCrawlMark& stackMark, Boolean forIntrospection)
at System.Reflection.Assembly.Load(String assemblyString)
at System.Web.Configuration.CompilationSection.LoadAssemblyHelper(String assemblyName, Boolean starDirective)
Request information:
Request URL: [redacted]
Request path: /
User host address: [redacted]
User:
Is authenticated: False
Authentication Type:
Thread account name: IIS APPPOOL\[redacted]
Thread information:
Thread ID: 8
Thread account name: IIS APPPOOL\[redacted]
Is impersonating: False
Stack trace: at System.Web.Configuration.CompilationSection.LoadAssemblyHelper(String assemblyName, Boolean starDirective)
at System.Web.Configuration.CompilationSection.LoadAllAssembliesFromAppDomainBinDirectory()
at System.Web.Configuration.CompilationSection.LoadAssembly(AssemblyInfo ai)
at System.Web.Compilation.BuildManager.GetReferencedAssemblies(CompilationSection compConfig)
at System.Web.Compilation.BuildManager.GetPreStartInitMethodsFromReferencedAssemblies()
at System.Web.Compilation.BuildManager.CallPreStartInitMethods(String preStartInitListPath, Boolean& isRefAssemblyLoaded)
at System.Web.Compilation.BuildManager.ExecutePreAppStart()
at System.Web.Hosting.HostingEnvironment.Initialize(ApplicationManager appManager, IApplicationHost appHost, IConfigMapPathFactory configMapPathFactory, HostingEnvironmentParameters hostingParameters, PolicyLevel policyLevel, Exception appDomainCreationException)
Custom event details:
查看 webroot，该bin文件夹确实包含 Magick.NET-x86.dll（以及 Magick.NET-Q16-x86.dll 和 Magick.NET-Q16-x86.Native.dll），并且该IIS_IUSRs组确实具有对这些的读取权限DLL（以及所有其他）。
虽然它是 64 位服务器，但 AppPool 确实将Enable 32-bit applications设置为True。将 AppPool 的托管管道模式从集成更改为经典也没有效果。但是，我确实注意到，AppPool 的应用程序数量被列为零（尽管网站的高级设置对话框显示了正确的 AppPool 名称）：
我完全不知所措，我们现在在迁移此应用程序方面落后于计划，因此我们将不胜感激地收到任何建议。
谢谢！
编辑添加：在 Github 上的票 #107 上有更多信息。