I have been using Genymotion on OS X 10.8 but after I updated it to Mavericks, the Genymotion device does not work properly. The three buttons which should be at the bottom appear at the top. However the touch is uneffected. Thus while the buttons are shifted to top, they are sensitive to touch only when touched at bottom. Here is a sample screenshot
Edit - One of the answers suggest that the problem might also depend on the Mac model I am using. I am using a 13" Macbook Retina Pro.
Edit 2 - A couple of applications are also running upside down. For example, the Music App