Are any of the many command-line options likely to help?
The tspsol
command line applicaton (based on the GLPK C library) or the C API in glptsp.h are tailor-made for solving TSP.
Is it reasonable to expect GLPK to solve a 100 node tour or greater in a practical time frame (say, less than 4 hours)? When does the problem size become intractable?
My guess is that it also greatly depends on the problem instance as well. If you look into the C code, you will see that heuristics are used to generate an initial tour. How well a heuristic works, well...
I assume you know that the TSP is famous for being difficult to solve, see computational complexity.