You can change the ItemsPanelTemplate of an ItemsControl so it uses a Canvas instead of a StackPanel to hold its items, then use the ItemContainerStyle to bind the Canvas.Top and Canvas.Left properties to your data object to position them.
<ItemsControl ItemsSource="{Binding MyCollection}">
<!-- ItemsPanelTemplate -->
<ItemsControl.ItemsPanel>
<ItemsPanelTemplate>
<Canvas />
</ItemsPanelTemplate>
</ItemsControl.ItemsPanel>
<!-- ItemContainerStyle -->
<ItemsControl.ItemContainerStyle>
<Style>
<Setter Property="Canvas.Top" Value="{Binding Y}" />
<Setter Property="Canvas.Left" Value="{Binding X}" />
</Style>
</ItemsControl.ItemContainerStyle>
</ItemsControl>
I have a blog article about the ItemsControl that explains in more detail how an ItemsControl works if you're interested.