I'm using the YouTube API to display a video in the browser that takes up the entire viewable area. In every other browser I've tried it on (Chrome 23, IE 9, Safari 5, Chrome on Android), the close icon overlay is clickable while the video is playing (click link, see top right):
It doesn't work in Safari on IOS 5.1.1. Is there anything I can do aside from creating a header and forcing the video not to take up the full height of the viewable area?