There are a couple of possibilities here.
Several of these require semi-well formed XML to work. If you don't have it, I would pair clj-tagsoup with hiccup to produce the XML (parse with clj-tag-soup, which produces a form that hiccup and write out as XML) and work with that.
First, just use the native JDK capabilities. Assuming the document is well formed enough, try using clj-xpath which provides a wrapper around the native JDK parsing.
If that doesn't suffice, consider taking a more Clojure data structure based route. A simpler path could just use the output of TagSoup and a combination of maps, filters, and nths.
If you need something more advanced, consider using zippers to provide structure around the data, making it easier to manipulate. Use clojure.xml/parse
and clojure.zip/xml-zip
to produce the zipper, and go from there. An example can be found at http://techbehindtech.com/2010/06/25/parsing-xml-in-clojure/.
Using the native structures is my preferred route for anything complicated, as you can bring the full power of the language to bear.
If you provide a sample of why you need XPath, I can provide some sample code.